Amy Mackos

Image

First Name

Amy

Last Name

Mackos

Credentials

PhD

Associate Clinical Professor

Director of Biomedical Research

mackos.3@osu.edu

Amy.Mackos@osumc.edu

614-292-4206

she/her/hers

Address

034C Newton Hall

Address (Line 2)

295 W. 10th Ave.

City

Columbus

State

Zip Code

43210

Dr. Amy Mackos joined the College of Nursing in 2017. She is a two-time Ohio State graduate with an extensive background in psychoneuroimmunology, microbiology, and genomic-based research. During her graduate work she played an integral role in the seminal discovery that psychological stress significantly impacts the shape and function of the gut microbiome. Her overarching research interest is dedicated to understanding how stressor exposure impacts health and disease with a focus on elucidating the bidirectional communication between the host and resident microbes. In addition to research, she is passionate about teaching, both inside the lab and the classroom. She has taught at the undergraduate, graduate, and professional levels. Currently, she is the course lead for N7450 Pathophysiology of Altered Health States and N7781 Responsible Conduct of Research.

View publications

Chapters

Mackos AR, Varaljay VA, Maltz R, Gur TL, Bailey MT (2016). Role of the Intestinal Microbiota in Host Responses to Stressor Exposure. International Reviews in Neurobiology. 2016; 131:1-19.
Mackos AR, Bailey MT (2016). Neuroendocrine regulation of infectious disease. Psychoneuroimmunology Research Society Primer of PNI Research.
Powell ND, Allen RG, Hufnagle AR, Sheridan JF, Bailey MT (2011). Stressor-induced alterations of adaptive immunity to vaccination and viral pathogens. Immunology and Allergy Clinics of North America. Feb;31(1):69-79.

Publications

Bulgart HR, Neczypor EW, Wold LE, Mackos AR (2020). Microbial involvement in the development and progression of Alzheimer Disease. Molecular Neurodegeneration; Jul 24;15(1):42.
Nowak AL, Anderson CM, Mackos AR, Neiman E, Gillespie SL (2020). Stress during pregnancy and epigenetic modifications to offspring DNA: A systematic review of associations and the implication for preterm birth. Journal of Perinatal and Neonatal Nursing; Apr/June 34(2):134-145.
Mackos AR, Allen JM, Kim E, Ladaika CA, Gharaibeh R, Parry NM, Boyaka PN, Bailey MT (2019). Mice deficient in IKKβ in epithelial or myeloid cells have distinct colonic microbiomes and increased resistance to Citrobacter rodentium infection. Frontiers in Immunology; Sep 10;10:2062.
Allen JM, Jaggers RM, Solden LM, Loman BR, Davies RH, Mackos AR, Ladaika CA, Berg BM, Chichlowski M, Bailey MT (2019). Dietary oligosaccharides attenuate stress-induced disruptions in immune function and microbial B-vitamin metabolism. Frontiers in Immunology; Apr;68(4):533-540.
Maltz RM, Keirsey J, Kim SC, Mackos AR, Gharaibeh RZ, Moore CC, Xu J, Bakthavatchalu V, Somogyi A, Bailey MT. Social Stress Affects Colonic Inflammation, the Gut Microbiome, and Short Chain Fatty Acid Levels and Receptors. Journal of Pediatric Gastroenterology and Nutrition; 2019 Apr;68(4):533-540.
Galley JD, Mackos AR, Varaljay VA, Bailey MT (2017). Stressor exposure has prolonged effects on colonic microbial community structure in Citrobacter rodentium-challenged mice. Scientific Reports; Mar 27;7:45012.
Lafuse WP, Gearinger R, Fisher S, Nealer C, Mackos AR, Bailey MT (2017). Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System. Journal of Immunology; Mar15;198(6):2383-2393.
Mackos AR, Maltz R, Bailey MT (2017). The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation. Hormones and Behavior;Feb;88:70-78.
Mackos AR, Galley JD, Eubank TD, Easterling RS, Parry NM, Fox JG, Lyte M, Bailey MT (2016). Social stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri. Mucosal Immunology; Mar;9(2):515-26.
Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M (2011). Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behavior and Immunity. Mar;25(3)397-407.

News

June 11, 2025

Jane E. Heminger Hall earns WELL Gold certification for health and wellness-centered design

College of Nursing home is first building at Ohio State to earn designation

The International WELL Building Institute (IWBI) has awarded The Ohio State University College of Nursing’s Jane E. Heminger Hall WELL Gold Certification for its construction and design features that promote and support health and well-being. It is the first building at Ohio State to earn this designation.

May 27, 2025

Tornwall awarded Fulbright U.S. Scholar award to Kyrgyzstan

Joni Tornwall, clinical professor, College of Nursing, has been awarded a 2025-2026 Fulbright U.S. Scholar Award to Bishkek, Kyrgyzstan to teach student-centered nursing practices at Kyrgyz State Medical Academy.